Royal Air Force Typhoon FGR4s have operated alongside French aircraft in a combined operation on an hidden munitions depot in Syria employed by the IS group, as stated by the UK Ministry of Defence.
The location, identified by surveillance, was assessed as containing munitions and bombs, the announcement noted, and was situated in hills just north of the ancient city of Palmyra in central Syria.
"Our fighter planes employed laser-guided Paveway IV weapons to target a number of entry passages leading to the site... preliminary assessments suggest the objective was successfully hit," the ministry announced.
There was no indication of any harm to civilians in the operation on Saturday evening and every plane involved made a safe return, the MoD added.
The Typhoon FGR4s were supported by a Voyager refuelling tanker.
The Islamic State group - referred to as Daesh - established militant control over significant areas in both Syria and Iraq until 2019.
"This action shows British leadership, and determination to stand shoulder to shoulder with our allies, to eliminate any resurgence of Daesh and their violent and radical beliefs in the Middle East," the British Defence Secretary the Defence Secretary stated.
British military aircraft have conducted patrols over Syrian airspace to "forestall any attempted comeback" of IS following its defeat at the Baghuz confrontation in the year 2019, the ministry said.
"I must thank all the members of our armed forces involved in this operation for their professionalism and their bravery," the Defence Secretary said. "They were part of thousands of British personnel deployed over the holidays. This action, to eliminate militants who threaten our safety, demonstrates how our armed forces are ready to step up, throughout the year, keeping Britain secure within its borders and strong abroad."
Last December, the US military carried out what it called a "major assault" against Daesh sites in Syria, following an ambush claimed the lives of two American soldiers and a local interpreter in the Palmyra area.
The U.N. says Islamic State still has roughly 5-7 thousand fighters in Syria and Iraq.