Van de Ven Double Halts Everton's Run at New Stadium
Micky van de Ven became the initial backline player to score twice in a English top-flight match for Tottenham since the Belgian defender in spring 2013.
At a glance
Micky Van de Ven heads home two times in first half
Everton's defender has goal disallowed after video check
Senegalese midfielder scores final goal in dying moments
This loss is Everton's first at Hill Dickinson Stadium
Micky van de Ven scored twice as Tottenham prolonged their unbeaten run on the road in the Premier League and delivered the Toffees their first defeat at Hill Dickinson Stadium.
The Toffees were undefeated in their five previous fixtures at their new ground at the dockside location, having departed their historic home behind after 133 years at the conclusion of last season.
But Tottenham's leader Van de Ven struck twice from corners in the first half to put their strong form at jeopardy, and they were failed to mount a comeback before the midfielder - set up by ex-Everton forward Richarlison - headed home a third to seal the victory.
Jake O'Brien believed he had equalized the tally a short while after Van de Ven's opener, directing a powerful header past the Spurs keeper from an Everton corner.
The Portuguese striker, in the meantime, failed to convert a number of opportunities, while Vicario made a succession of fine saves to guarantee Tottenham went five matches on the road unbeaten in the English top flight.
But the video assistant referee intervened, advising the match official to check the goal on the screen and the referee decided that Jack Grealish and Iliman Ndiaye were in an illegal position and had impeded with the Tottenham goalkeeper.
The win elevates the manager's team into third place in the Premier League, five points off north London rivals and table-toppers the Gunners.
Everton stay 14th and sit six points ahead of the drop zone.
Spurs breakdown: The defender excels in role at both ends of pitch
Following a drab midweek display in the European competition against the French side, where they managed a mere attempts on goal, Frank chose Randal Kolo Muani in attack instead of ex-Everton forward the Brazilian.
The new arrival was failed to influence the game before being replaced for the substitute after an hour on the field, but it emerged he wasn't needed in the end.
Defender the Dutchman converted into an offensive threat to be reckoned with.
Tottenham's opening strike came from a cleverly executed set-piece play, with the midfielder heading the ball toward the face of goal for an unmarked the defender to score.
And the captain - stepping up as skipper in the Argentine's absence - notched his second in first-half stoppage time as he outjumped the England keeper to nod in.
Van de Ven was equally outstanding in defence, partnering effectively with his defensive colleague as the duo dealt excellently with the 34 crosses sent their way by the opposition.
Everton analysis: Toffees missing striker's instinct
Everton's new home had been a happy hunting ground, but it seems the novelty may have worn off slightly and fans flocked to the exits after Sarr's third for Spurs.
The break in Everton's winning streak at home will not be a major concern for the manager, but their attacking woes are.
Beto and Thierno Barry - the Toffees' pair of established strikers - had scored only one league goal between them before Sunday's match.
And they were unable to contribute to that miserable tally on a wet and gloomy night on in Liverpool.
The striker's performance was epitomized when he opted to overhead kick a clear chance from near the goal, even with having space and time to readjust for a simpler attempt that would have tested Vicario.
Barry, as well, was unable to influence the game after replacing the starter in the 65th minute.
It was not for a shortage of opportunity. Most of Everton's attacks came through the winger and the forward, who tirelessly delivered dangerous balls into the Spurs penalty area.
Upcoming fixtures for both teams?
The Toffees: Moyes' men head to the Stadium of Light in the Premier League on Monday, 3 November at 20:00 GMT.
Spurs: Spurs go to St James' Park on Wednesday, 29 October for their next round League Cup match against Newcastle.